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2008 Louisville Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 11/22/2008 | 05:30 PM | Morehead State | W, 79-41 | 1-0 |
| 11/23/2008 | 04:00 PM | South Alabama | W, 81-54 | 2-0 |
| 11/30/2008 | 03:00 PM | at Western Ky | L, 68-54 | 2-1 |
| 12/06/2008 | 02:00 PM | Indiana State | ||
| 12/07/2008 | 04:00 PM | Ohio | ||
| 12/08/2008 | 07:00 PM | Lamar | ||
| 12/13/2008 | 01:00 PM | Austin Peay | ||
| 12/18/2008 | 09:00 PM | Ole Miss | ||
| 12/20/2008 | 02:00 PM | Minnesota | ||
| 12/27/2008 | 04:00 PM | U-A-B | ||
| 12/31/2008 | 06:00 PM | U-N-L-V | ||
| 01/04/2009 | TBA | Kentucky | ||
| 01/07/2009 | 07:00 PM | at South Florida | ||
| 01/10/2009 | 12:00 PM | at Villanova | ||
| 01/12/2009 | 07:00 PM | Notre Dame | ||
| 01/17/2009 | 06:00 PM | Pittsburgh | ||
| 01/21/2009 | 07:00 PM | at Rutgers | ||
| 01/25/2009 | 12:00 PM | at Syracuse | ||
| 01/28/2009 | 07:00 PM | South Florida | ||
| 01/31/2009 | 12:00 PM | West Virginia | ||
| 02/02/2009 | 07:00 PM | Connecticut | ||
| 02/08/2009 | 01:30 PM | at St Johns | ||
| 02/12/2009 | 07:00 PM | at Notre Dame | ||
| 02/15/2009 | 04:00 PM | DePaul | ||
| 02/18/2009 | 07:30 PM | Providence | ||
| 02/21/2009 | 02:00 PM | at Cincinnati | ||
| 02/23/2009 | 07:00 PM | at Georgetown | ||
| 03/01/2009 | 12:00 PM | Marquette | ||
| 03/04/2009 | 07:00 PM | Seton Hall | ||
| 03/07/2009 | 09:00 PM | at West Virginia |
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