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2008 Rice Owls Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 08/29/2008 | 08:00 PM | S-M-U | W, 56-27 | 1-0-0 |
| 09/06/2008 | 08:00 PM | at Memphis | W, 42-35 | 2-0-0 |
| 09/13/2008 | 07:00 PM | at Vanderbilt | L, 38-21 | 2-1-0 |
| 09/20/2008 | 07:00 PM | at Texas | L, 52-10 | 2-2-0 |
| 09/27/2008 | 05:00 PM | North Texas | W, 77-20 | 3-2-0 |
| 10/04/2008 | 08:00 PM | at Tulsa | L, 63-28 | 3-3-0 |
| 10/18/2008 | 03:00 PM | Southern Miss | W, 45-40 | 4-3-0 |
| 10/25/2008 | 03:00 PM | at Tulane | W, 42-17 | 5-3-0 |
| 11/01/2008 | 09:05 PM | at Texas-El Paso | W, 49-44 | 6-3-0 |
| 11/08/2008 | 03:00 PM | Army | W, 38-31 | 7-3-0 |
| 11/22/2008 | 03:30 PM | Marshall | ||
| 11/29/2008 | 03:30 PM | Houston |
